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Covariates that are known to affect epigenetic marks should be collected where possible, including age 136 , smoking status 137,138 , body mass index (BMI) 139,140 , alcohol use 141,142 , exposure to a range of environmental toxicants 143,144 , medications 145,146 , comorbid diseases 147,148 and exercise regimen 149

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Our operating companies delivered excellent key-brand performance in the third quarter, and that helped drive further gains in Reynolds Americans net sales, earnings and margin, said Cameron