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In order to compare the three groups defining smoking status (current, former, and never smokers) in terms of continuous variables (such as age, age of disease onset, length of CH, length of active periods, and maximum number of attacks/day), means and standard deviations (SD) for each group were calculated and the one-way analysis of variance (ANOVA) was conducted, followed by Newman-Keuls post-hoc testing

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Dosage: 2000 mg before breakfast, lunch, and mid-afternoon as needed