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After exposed to different levels of H 2 S (0, 5, 10, and 15 mg/m 3 ) for 28 days, the abundance of Firmicutes and Proteobacteria were increased and the abundance of Bacteroides were decreased in the weaning pigs ( Effect of Heavy Metals on Intestinal Microbiota Cigarette smoke contains many heavy metals (such as cadmium, arsenic, lead, chromium, iron, mercury, nickel, and vanadium), which are inhaled into the lungs as aerosol particles or free in a gaseous state (Satarug et al., 2003)