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Tobacco includes more than three thousand different compounds, whereas cigarette smoke contains more than four thousand different chemicals, including hazardous substances, of which fifty are particularly cariogenic and cause dental cavities

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Journal of Analytical Toxicology

Cigarettes were described as coffin nails as early as the 1890s, and newspapers throughout the 1800s were full of advertisements for medicines guaranteed to cure the tobacco habit, most of which warned against the dreaded disease known as tobacco heart. Tobacco heart was recognized as a legitimate disease by practicing physicians