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4 Effects of tobacco smoke on metabolism of antidiabetic medications The treatment options for type 2 diabetes mellitus (T2DM) include various drug classes such as sulfonylureas (SUs), glinides (or meglitinides), biguanides, thiazolidinediones (also known as glitazones), -glucosidase inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and sodium-glucose linked transporter-2 (SGLT-2) inhibitors