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Most Addictive Substances Ranked Five Topmost Addictive Substances in the World Nicotine is highly addictive, especially for teens. Nicotine can affect attention, mood, learning, and impulse control while the brain is still developing. Many vaping products contain high levels of nicotine, making it Most tobacco products, including e cigarettes, contain nicotine, a chemical that can harm the heart, brain and whole body. As with other addictive products, using a nicotine product builds tolerance, leading to more

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