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The demand that followed lit a commercial fire that turned Durham from a crossroads into a city within a generation

Though scientists are not entirely certain, they think that the hallucinogenic properties are related to Ibogaine's interaction with the kappa-opioid (KOR) and 5-HT2A receptors in the brain, which is also how other hallucinogens like salvia and Mescaline work (via "Progress in Brain Research: Psychedelic Neuroscience")

At age 63, George Clooney made his Broadway debut this spring, starring in an adaptation of the 2005 Oscar-nominated movie, "Good Night, and Good Luck." The play broke box office records and was nominated for five Tony Awards