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Power levels that produce aerosol beyond the ability of the wick to resupply the liquid to the coil may result in overheating of the atomizer coil and consequently overheating of the e-liquid 10,11

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To further investigate whether current e-cigarette use was associated with less consumption of tobacco or nicotine, in SPIROMICS we examined both tobacco-specific urinary metabolites (anabasine) and urinary nicotine metabolites that are present with both conventional and e-cigarette use (Fig