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Although the mechanism by which smoking influences vWF release is not fully understood, it has been suggested that lipid peroxidase formed by O2 free-radicals and the effects of nicotine and CO2 contribute to the increase in vWF functional activity 28

Acknowledgements The authors thank the team at the West China Biomedical Big Data Center and the UK Biobank project for their support and collaboration

Keep the space ventilated as you work.

Crucially, neglecting cohort-related smoking patterns undoubtedly will lead to erroneous interpretation of trends, inappropriate conclusions about the efficacy of tobacco control policies, and inaccurate projections of cigarette consumption