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Current use among high school students increased from 1.5 percent in 2011 to 4.5 percent in 2013, then tripled to 13.4 percent in 2014

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In one such study, rats exposed to methylglyoxal or diacetyl exhibited significantly more necrosis in the nasal and bronchiolar epithelium following methylglyoxal exposure ( Multiple toxicological effects associated with acetaldehyde and methylglyoxal were observed in both EpiAirway tissues and cultured BEAS-2B cells