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The first hint of this intriguing phenomenon came in 1969, when researchers tested caffeines effect on blood pressure in rats

Nicotine & Tobacco Research 2007;9(12):12517

If the patient is not willing to quit, use a motivational approach, explore barriers and review at future visits

These make the CYP1A2 enzyme work faster That means the enzyme breaks down clozapine quicker, so you get less effect from it But if you stop smoking that means that the enzyme slows back down to its normal speed This means that: o The liver doesnt break clozapine down as fast as it did before o Your blood level of clozapine goes up (because the body isnt getting rid of it as fast) o You may get side effects from having too high a blood level of clozapine (the same as having a higher dose) The effect can be huge, sometimes the same effect as almost doubling your dose This effect can be even more marked if you are also taking a medicine called sodium valproate If you stop smoking this effect may start in 3-5 days