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Thermal profiling was performed using a Veriti Thermal Cycler (Bio-Rad, Bio-Rad Laboratories, USA) across an 8-point temperature gradient (37.0, 41.0, 45.0, 49.0, 53.0, 57.0, 61.0, and 65.0 C)

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ARA-290 does not trigger that pathway

Neurochem Res 30(3):403410 Porciuncula LO, Rocha JB, Boeck CR, Vendite D, Souza DO (2001) Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons