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Several novel markers such as IGFBP-1, hs-CRP, adiponectin, ferritin, HbA1c, C3 complement, TNF alpha and sCD36 are now surfacing as surrogate markers of IR.[17] Other investigations for IR are fasting glucose and lipoprotein profile, hemoglobin A1c, body weight, blood pressure, and an alanine transferase test for evaluation of fatty liver.[6] ACANTHOSIS NIGRICANS AND CARDIOVASCULAR DISEASE Insulin resistance is thought to be a primary etiological factor in the development of cardiac dysfunction, higher prevalence being reported in nonischemic heart failure population

doi: 10.3390/ijms251910606 115 YunusM

doi: 10.1186/s12862-018-1214-1 48 NunesSCRamosCLopes-CoelhoFSequeiraCOSilvaFGouveia-FernandesSet al

1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Abeta1 = 40 brain-to-blood efflux and peripheral uptake transport