Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-PNP pnp eliminating the need for a

eliminating the need for a catalyst

Product Name [4-(methoxy-d3)phenyl]methanol Synonyms [4-(²H3)methoxyphenyl]methanol CAS Number 14629-71-1 Related CAS Molecular Formula C8H10O2 Molecular Weight 141

The inhibiting SHP2 activity of SHP099 is through an allosteric mechanism

Product Name Thalidomide-O-C3-Br Synonyms Thalidomide-4'-O-C3-Br CAS Number n/a Related CAS Molecular Formula C16H15BrN2O5 Molecular Weight 395

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-PNP pnp eliminating the need for aSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating