acetaminophen glutathione toxicity Paracetamol Too much paracetamol = dangerous

Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Paracetamol (Acetaminophen) hepatotoxicity and its management. Acetaminophen overdose resulting in massive hepatic necrosis. Note the scant residual periportal hepatocytes. #liverpath #hepatology Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect

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