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An increased expression of SphK2 was found in MM cells as well as in MM patient PCs, where short hairpin RNA-mediated knock-down, or pharmacological inhibition of SphK2 by the selective inhibitor ABC294640, induced apoptosis via caspase-3 activation, overcoming the protective effect of BMSCs

10.1002/ptr.8179 50 GhoushiE.PoudinehM.ParsamaneshN.JamialahmadiT.SahebkarA

Additionally, we demonstrated that anisomycin inhibited the downstream activation of the Notch1 pathway by attenuating the molecular sponge effect of the lncRNA- Meg3 /miR-421/platelet derived growth factor receptor alpha (PDGFRA) axis, ultimately inhibiting the angiogenesis, proliferation, and invasion of ovarian cancer cells [13]