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Oral administration of high-dose vitamin B 12 (1 to 2 mg daily) is considered as effective as intramuscular administration for correcting anemia and neurologic symptoms Despite many studies suggesting oral administration of vitamin B 12 to be easy, effective and less costly than intramuscular administration, debate surrounds the effectiveness of the oral route

[] Further exacerbating this dysfunctional landscape is an impairment in mitophagy clearance, as evidenced by reduced levels of PINK1 and Parkin in failing human hearts