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Oxidative stress, oxidative eustress, and oxidative distress The term oxidative stress in relation to biological systems appeared for the first time in the scientific literature in the early 70s (Azzi 2022)

Symptoms of overmethylation can include: [23] Restless legs/pacing Hyperactivity High pain tolerance Histamine intolerance Sleep disorders Panic disorders Paranoia Insomnia Low libido ADHD Low motivation Depression Anxiety High levels of neurotransmitters (dopamine, norepinephrine, and serotonin) A high copper to zinc ratio Generally, undermethylation will result in symptoms more akin to depression and sluggishness, while overmethylation is usually linked to symptoms like hyperactivity and anxiety

Pelttari, K., Wixmerten, A

Curcumin is being tested for use as an alternative anti-CCA agent 10,11