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Epithelial transport in digestive diseases: mice, monolayers, and mechanisms

37 Treatment for CRPS, ranging from 40 mg to 80 mg infused over 4 hours daily for 10 days, with supplemental oral clonidine 0.1 mg and midazolam 2 to 4 mg for increased tolerability, was successful, with outcomes of improved mobility by day 10, reduction in the number of individuals experiencing pain by day 10, as well as a reduction in the level of their worst pain

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7-selective type II positive modulators can disrupt the desensitized state and facilitate the opening of ion channels