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Whether apoE deficiency also impacts the lipid metabolism of the brain is currently a major topic of discussion, but more detailed studies are required to understand the exact mechanism of APOE4 function in neuronal lipid metabolism (Liu et al

However, DFP demonstrated inconsistent efficacy in other neurodegenerative diseases (Pandolfo et al., 2014)

Conversely, interventions that have combined IF with exercise have been proved feasible and suggest that participants are able to perform moderate- to high-intensity endurance or resistance exercise during extended periods of fasting (Reference Bhutani, Klempel and Kroeger32,Reference Kotarsky, Johnson and Mahoney67,Reference Moro, Tinsley and Bianco74)

Bioorg Chem 90:103073 Kretzschmar M, Mller D (1993) Aging, training and exercise