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Bosello-Travain V, Conrad M, Cozza G, Negro A, Quartesan S, Rossetto M et al (2013) Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7

It is standard practice in Bayesian trial design methodology 55 to use a community of priors, also known as adversarial priors, whereby an enthusiastic prior is used for futility monitoring while a more skeptical prior is used for the final analysis