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The key features of this experimentally-induced inflammation include increase in vascular permeability and leucocytes infiltration, which lead to paw edema within the inflamed foci 8,9,10

Multiple factors contribute to mitochondrial complex I dysfunction, affecting energy metabolism and exacerbating oxidative stress, which damages neurons, and PINK1/Parkin-mediated mitochondrial autophagy is disturbed by mutations in PD-associated genes and aberrant expression of deubiquitinating enzymes, imbalances in mitochondrial dynamics, and aberrant interactions with other organelles, which all contribute to the progression of PD [159]

5,6 GSH has a variety of physiological effects