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Following the transfer of aminopropyl groups, dcSAM transforms into 5-deoxy-5-methylthioadenosine, which then can undergo a series of steps in the Met salvage pathway to regenerate adenine and Met (Lauinger and Kaiser, 2021)

19 TABLE 4 Schedule for Vitamin B12 Therapy Follow-Up After the diagnosis of vitamin B 12 deficiency has been made and a treatment plan has been initiated, follow-up is important to determine the patient's response to therapy

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The magnitude of the NAD + -elevation effect of NNMT inhibition in vivo, and its contribution to the metabolic phenotype relative to the methylation effects, remains an active area of research