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JP-8exposed animals also demonstrated a nonsignificant decrease in performance on the rotarod test when compared to unexposed controls, whereas no rotarod performance differences were observed following exposure to petroleum- or shale-derived JP-5

In the food chain of algae to sea angel, Clione limacina , AST is found to be produced from the oxidative metabolism of -carotene, -cryptoxanthin and zeaxanthin

This pathway is considered the most genotoxic as the 4-OH estrogen metabolites can become reactive quinones that have the potential to bind to DNA and form damaging (unstable) depurating adducts, that may increase risk for cancer, such as breast and prostate cancer

Murata et al