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Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

10.3390/biom5020356 100 St-PierreJ.BuckinghamJ

Collectively, these properties lead to a hypoxic state and accumulation of metabolic waste products that favor the recruitment of macrophages, T reg cells and MDSCs, while inhibiting CD4 + and CD8 + T cells, NK cells, and DCs [110, 113, 114]