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The answer depends on several factors including peptide type, molecular modifications (such as PEGylation), dosing frequency, and delivery route

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Then, we used the AMPK inhibitor compound C (CC) and found that the therapeutic effect of TP-10@CaP-CTP on cardiac hypertrophy was blocked by CC, as indicated by the CM cell surface area (Fig

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Moreover, cAMP can lead to AMPK activation in a protein kinase A (PKA)- or exchange protein activated by cAMP (EPAC)-dependent manner 31

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