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Dose-dependent organ toxicity, long-term safety profiles, and potential interactions with medications commonly administered to AKI patients, such as antibiotics, vasopressors, and nephrotoxic agents, must be systematically evaluated

It activates mitogen-activated protein kinase (MAPK)/nuclear factor kappa-B (NF-B) signaling pathways with subsequent elevation in the gene expression of numerous inflammatory cytokines as interleukin (IL)-1, IL-6, and tumor necrosis factor- (TNF-) (Zhu et al

Since we demonstrated in a previous study that mitochondria in Wobbler motor neurons have abnormal morphology (Stein et al., 2021) and mitochondrial malfunction is known to be present in Wobbler animals (Xu et al., 2001

The indexed library was purified using Sera-Mag Select beads (Cytiva)