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This solution was added to 100150 L of preformed MA vesicles (25 mM MA, 10 mM HEPES, 1 mM Mg-Citrate, 100 mM KCl, 0.2 M bicine, pH 8.5) and 200250 L of buffer (4 mM MA micelles, 10 mM HEPES, 1 mM Mg-Citrate, 100 mM KCl, 0.2 M bicine, pH 8.5) to obtain a solution containing 0.5 M RNA (non-encapsulated) and 8.811 mM MA

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Targeting lysosomal protease CTSL promotes anti-tumor immunity and sensitizes HNSCC to PD-1 blockade by stabilizing PDK1 and activating Akt-PD-L1 axis

Cardiovascular risk factors induce ROS production, triggering oxidative stress and leading to disease