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Integrated stress response Studies in various models of mitochondrial dysfunction have consistently identified an activation of the integrated stress response (ISR)

The ubiquitin-proteasome-mediated proteolytic system regulates the expression and activity of various proteins involved in cellular processes such as the cell cycle, proliferation, and apoptosis [44]

Reproductive and developmental studies in rats and mice from the published literature identified adverse events at clinically relevant doses with acetaminophen

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