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Description

L.SandersM

SIRT1 deacetylates FOXO1 to protect mitochondria from oxidative stress, which limits FOXO1s potential to cause cell death 124

C.LucheseC.et al

No receptor-mediated adverse events (e.g., cardiovascular effects, endocrine disruption) have been reported, consistent with NNMT's limited expression outside metabolic tissues