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Statello L, Guo CJ, Chen LL, Huarte M

The recommended dosage of Pemetrexed Injection when administered with cisplatin for initial treatment of locally advanced or metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m2 as an intravenous infusion over 10 minutes administered prior to cisplatin on Day 1 of each 21-day cycle for up to six cycles in the absence of disease progression or unacceptable toxicity

In both MASLD and ALD, the presence of abnormal lipids can result in lipid toxicity, leading to subsequent inflammation, oxidative stress, ERS, and other related pathologies