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(I could further the metaphor and liken the Windows blue screen of death to some kind of psychotic break, but that may be taking it a bit too far.) What is causing the structural changes to the brain, to the heart, to the immune system

212 In a clinical trial involving 35 individuals with specific MTHFR gene mutations, 1.6 mg of vitamin B 2 per day for 12 weeks lowered homocysteine levels significantly more than placebo and the effect was stronger in those with suboptimal B 2 status

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Biol Trace Elem Res 107(3):231