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For example, the redox activitiy of p66Shc within mitochondria has been shown to generate H 2 O 2 in the absence of superoxide through oxidation of cytochrome c ( 2 O 2

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Int J Biol Sci 18:4690 Papapanou M, Papoutsi E, Giannakas T, Katsaounou P (2021) Plitidepsin: Mechanisms and clinical profile of a promising antiviral agent against COVID-19