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Looking to the next generation of obesity treatments, combinations of GLP-1 with other entero-pancreatic hormones with complementary actions and/or synergistic potential (such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin) are under investigation to enhance the WL and cardiometabolic benefits of GLP-1 RA

In the initial dose-finding studies, three concentrations of Cagrilintide ranging from 3, 30, and 300 nmol/kg, were tested in chow-fed WT mice

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These are relatively small changes that the mucosa can handle thanks to its regenerative abilities