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Notably, even in the absence of FOXO4 FH , we observed an -helical population of TAD1, which slightly increased in presence of FOXO4 FH

As the WL achieved with the novel obesity pharmacotherapies approaches that of bariatric surgery, we will need to assess whether long-term complications observed after bariatric surgery such as increased risk of osteoporosis, fractures, macro- and micronutrient deficiencies as well as self-harm behaviours will also be present with pharmacotherapy [112, 113]

We also found that PI3KAkt and MAPK signaling pathways were enriched, consistent with the results of GO analysis