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Elamipretide: the first cardiolipin-directed mitochondrial therapeutic for Barth syndrome approved under accelerated approval

2022 Dec 12;10(12):3221

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STRUCTURE OF THE GHK-CU PEPTIDE Amino acid sequence: Gly-His-Lys Molecular formula: CHNO + Cu Molecular weight: 340.88 g/mol (without copper ion) Form: blue lyophilizate (the characteristic color comes from the complex with the copper ion), easily soluble in water RESEARCH AND BIOLOGICAL ACTION GHK-Cu and skin regeneration GHK-Cu stimulates fibroblasts to increase production of collagen, elastin, and glycosaminoglycans, which improves the structure and elasticity of the skin