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Description

The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism

PLoS ONE 13 , e0195102 (2018)

N-Acetyl-Semax-Amidate, sometimes marketed with the shorthand NAS or NASA, extends that window and is reported anecdotally to produce a stronger subjective cognitive effect at similar milligram doses