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Studies have shown that increased TrxR enhances oncogenic processes in a number of ways, including enhancing tumor formation, inducing angiogenesis, and increasing resistance to cancer therapies (187)

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Although depletion of luminal Ca 2+ from the ER provokes a rapid and reversible shift towards a more reducing poise in the ER, the underlying molecular basis remains unclear

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Additionally, they suppress the NLRP3 inflammasome, downregulating IL-1 and mitigating inflammatory responses (Qiu et al., 2023)

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