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For patients with CNS3 disease, all of whom were assigned to receive high-dose methotrexate and 18 Gy of cranial radiation therapy, nelarabine was associated with significantly superior DFS.[19] Patients with initial induction failure (M3 marrow at day 29, n = 43) were nonrandomly assigned to receive high-dose methotrexate and nelarabine

Regrowth was found to be more successful if there were fewer than 5 patches, if the patches were less than 3cm in diameter, and if the lesions were less than 1 month old

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