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Although concomitant medication changes were not recommended throughout the study period, adjustments in antihypertensive and antidiabetic treatments were conceded in selected cases to avoid acute clinical complications during the trial

This acyl-chain length preference probably depends on the substrate specificity of acyl-coenzyme A synthetase enzymes (ACSs;EC 6.2.1.x), the activators of fatty acids, which form a thioester with CoA 20

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We identified Y211 as another residue of interest as it forms part of the carnitine binding site and is one residue downstream Na + -coordinating N210 on TM4