glutathione and fe Functionalized Fe-Doped Carbon Dots Exhibiting Dual Consumption to Amplify Ferroptosis for Enhanced Cancer Therapy Antioxidants are an important part of a healthy diet but are easily destroyed in digestion. Fluorescence and colorimetric dual-signal determination

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Another factor may be the heterogeneity of patient responses

On the other hand, inhibition of GSH synthesis with BSO, independently of the cysteine pool, has been repeatedly described to induce ferroptosis ( via depletion of mitochondrial GSH pool leading to the release of cytochrome c, when combined with chemotherapy in breast cancer and leukemia, respectively (71, 72)

Iron overload As a common trace element, iron is distributed in the liver, spleen and bone marrow of the human body, which is closely related to the hematopoietic function of body and is necessary to maintain the normal life activities of human [22, 23]