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Life Sci (1992) 50(26):205965

Identification of NAPRT inhibitors with anti-cancer properties by in silico drug discovery

showed that selenomethyl selenocysteine, sodium selenite and methyl selenite could enhance the inhibitory effect of cyclophosphamide on canine breast cancer cells by down-regulating the expression of VEGF, angiotensin II (Ang II) and HIF-1, which are related to the growth and vascularity of tumors, and by up-regulating the expression of phosphatase and tensin homologous genes (152)