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Peer review Peer review information Nature Medicine thanks Johannes Thrul and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Acta Pharm Sin 2(4):327334 Zhang Q, Piao X-L, Piao X-S, Lu T, Wang D, Kim SW (2011) Preventive effect of Coptis chinensis and Berberine on intestinal injury in rats challengedwith lipopolysaccharides

In cases where the skin is cracked, subcutaneous injection is not indicated

This decline is gradual but can be accelerated by external factors such as: Chronic stress Unbalanced diets low in antioxidants Pollution and toxin exposure Smoking and alcohol consumption Certain chronic diseases Natural cellular aging After the age of 50, the decrease becomes more pronounced, impacting the body's ability to combat oxidative stress and support the immune system