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The burden of glycated proteins can be estimated from the fact that diabetic individuals are more than 50% susceptible in developing cognitive disorders as compared to non-diabetic persons ( Previously, people used immunological techniques such as ELISA and immunoblotting for detection of glycated protein adducts which frequently led to overestimation of AGEs due to conversion of Amadori products into carboxy methyl lysine or pentosidines (Suzuki et al., 2022)

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MSR1 is highly expressed in macrophage clusters and may be involved in regulating M2-like macrophage polarization, knockdown of Msr1 inhibits M2-like macrophage polarization, and elevated MSR1 expression promotes macrophage polarization toward the M2 type (118, 119)

Nevertheless, most studies have mainly focused on the protective role of GPx in hypertension