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Description

Additionally, there is evidence to suggest that it can cross the blood-brain barrier

61,62 In contrast, CSCs frequently exploit signaling pathways that are not typically active or are tightly controlled in NSCs

Structures are available for Pf12 (PDB IDs 2YMO, 7S7R and 7S7Q), Pf41 (PDB IDs 4YS4 and 7S7Q) and Pfs48/45 (PDB IDs 6E62 and 6H5N) that were solved using different protein constructs that vary in sequence, amino acid range, or recombinant protein expression system ( Supplementary Table 1 )