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With regard to the relationship between BDNF and depressive disorders, there is evidence that expression and activity of BDNF in the hippocampus are decreased in response to stress and increased by antidepressant treatment [40,41,42,43]

Studies suggest that l-carnitine can increase muscle mass and decrease body weight, through fat oxidation and using muscle fat for fuel

The persistent state of immune activation in ME/CFS and Long COVID rapidly depletes the body's stores of essential nutrients, particularly those required for mitochondrial function

MRS in patients with L2HGA may show a decrease in N-acetylaspartate and choline, along with an increase in inositol peaks [51]