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Glutathione IV therapy is generally well tolerated when administered by trained medical professionals with proper screening

Multiple studies report elevated levels of LC3, p62, and Atg proteins, accompanied by reduced colocalization with lysosomal markers or delayed clearance of protein aggregates ( Substantial evidence supports mitochondrial dysfunction as a key mechanism in MPs/NPs neurotoxicity

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The depletion of GPX4 can increase the sensitivity of hepatocytes or cardiomyocytes to lipid peroxides, which can accelerate IRI-induced liver or cardiac injury [246,247,248]