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Biological biomolecules based on gene expression, epigenetic alterations, microRNA profiles, protein phosphorylation and cytokine signatures can contribute to the selection of subsets of these patients for specific natural agents, monitoring in vivo biological efficacy and potential synergistic (or antagonistic) interactions with medical therapies (223)

A randomized controlled trial involving 30 individuals administered 200 mg/d l-theanine for four weeks reported improved mental health by relieving stress and improving cognitive functions [38]