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comprehensive safety evaluations and the design of personalized therapeutic regimens for clinical application

You could argue that that failure implies that reducing IGF is irrelevant, reducing IGF is irrelevant once the tumor burden is established, reducing IGF to only 55% is irrelevant

For example, functional TGFB1 promoter polymorphisms correlate with greater circulating TGF-1, adverse clinical features, and dismal survival trajectory in patients with brain malignancies (59)