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Our group has lately demonstrated that AITC causes a shift in the cell cycle distribution, leads to a disintegration of microtubules and inhibition of the actin-dependent intracellular transport in A

The effect of this synergistic treatment is ASS-dependent, and the activity of the enzymes mentioned above can be restored by transfection of ASS, eliminating the sensitivity of tumor cells to ADI-PEG20 combined with 5-FU treatment